AOSD - Genes and Biomarkers Biomarker / Gene Bad Score Free Actions Non-free Actions GENES BIOMARKERS IL18 NLRP3 MIF Ferritin IL-18 CRP S100A8/A9 High-risk allele Anti-inflammatory diet IL-18 inhibitors GOF variant Avoid triggers, rest Anakinra, Canakinumab High-promoter allele Stress reduction MIF inhibitors >10,000 ng/mL Hydration, rest Anakinra (IL-1 blocker) >50,000 pg/mL Anti-inflammatory diet Tadekinig alfa >100 mg/L Rest, cold compresses NSAIDs, corticosteroids >10,000 ng/mL Stress management Tocilizumab