Chondrosarcoma — Genes & Biomarkers Summary
Gene / BiomarkerBad ScoreFree ActionsNon-free Actions
GENESBIOMARKERS
IDH1Mutation detectedSurveillanceIvosidenib
IDH2Mutation detectedGenetic counselingEnasidenib
COL2A1Aberrant expr.Regular imagingSurgical resection
TP53Loss of functionRisk assessmentChemotherapy
RB1Deletion/lossSurveillanceCDK4/6 inhibitors
CDKN2AHomoz. deletionImaging follow-upRadiation therapy
ATRXLoss of expr.Genetic counselingPARP inhibitors
TERTAmplificationMonitoringTelomerase inhib.
SMARCB1Loss of expr.Genetic testingEZH2 inhibitors
Ki-67Index > 10%Exercise & follow-upChemotherapy
p53OverexpressionMonitoringTargeted therapy
S100Absent/weakRegular imagingCore biopsy
MDM2AmplificationGenetic counselingMDM2 inhibitors
CDK4AmplificationMonitoringCDK4/6 inhibitors
VEGFHigh expressionDiet modificationBevacizumab
Sox9Low expressionSurveillanceSurgical resection