Compartment Syndrome — Genes & Biomarkers
Biomarker / Gene
Bad Score
Free Actions
Non-free Actions
GENES
MMP9
Overexpression (>3×)
Rest, ice, elevation
MMP inhibitor therapy
VEGF
Underexpression (<50%)
Hydration, stretching
Angiogenic therapy
IL-6
C/C genotype
Anti-inflammatory diet
IL-6 receptor blocker
TNF-α
A/A genotype
Cold compress, rest
Anti-TNF biologic
BIOMARKERS
Creatine Kinase
>1,000 U/L
Rest, oral hydration
Fasciotomy evaluation
Myoglobin
>200 ng/mL
Monitor urine output
IV fluids, dialysis
Lactate
>2 mmol/L
Elevate limb, ice
Surgical decompression
Compartment Pressure
>30 mmHg
Remove splint/cast
Emergency fasciotomy