Discoid Meniscus: Genes & Biomarkers Summary
Gene / Biomarker
Bad Score
Free Actions
Non-free Actions
GENES
COL2A1
Low expression
Low-impact sports; avoid overloading
Collagen type II supplements
MMP3
High activity (rs679620)
Cold therapy; reduce joint stress
MMP inhibitor Rx; doxycycline
ACAN
Low expression / variant
Weight control; posture training
Glucosamine sulfate; PT sessions
FBN1
Pathogenic variant
Avoid high-impact; daily stretching
Orthopedic brace; specialist consult
BIOMARKERS
hs-CRP
>3 mg/L
Anti-inflammatory diet; rest
Omega-3 supplements; NSAIDs
IL-6
>7 pg/mL
Sleep optimization; cold compress
IL-6 inhibitor Rx; corticosteroid
COMP
>12 U/L
Activity modification; swimming
Knee brace; hyaluronic acid inj.
CTX-II
>300 ng/mmol cr.
Low-impact exercise; weight loss
Bisphosphonate Rx; MRI follow-up
Rx = prescription required · PT = physical therapy · inj. = injection · cr. = creatinine