EDS Genes & Biomarkers — Summary TableGene / BiomarkerBad Score IndicatorsFree ActionsNon-free ActionsGENESCOL5A1Skin laxity, wide scarsPhysical therapyGenetic panelCOL3A1Arterial/organ rupture riskAvoid trauma, contact sportsCeliprolol, vascular MRITNXBHigh skin extensibilityBracing, proprioceptionGenetic panelPLOD1Scoliosis, muscle weaknessPT, spinal bracingEnzyme assay, surgeryCOL1A1Joint dislocations, fragilitySplinting, low-impact exerciseBisphosphonates, imagingBIOMARKERSTenascin-XLow serum levelSymptom diary, physioSerum assay, genetic panelMMP-1/3Elevated: tissue breakdownAnti-inflammatory dietLab panel, collagen biopsyTGF-βElevated: fibrotic activityStress managementSerum test, specialist