Ewing's Sarcoma — Genes & Biomarkers Summary Table
Ewing's Sarcoma — Genes & Biomarkers
Biomarker / GeneBad ScoreFree ActionsNon-free Actions
GENES
EWSR1::FLI1
Present (driver, ~85%)
Exercise, anti-inflam. diet
EWS/FLI1 inhibitors, trials
EWSR1::ERG
Present (rare fusion)
Genetic counseling, monitor
CDK4/6 inhibitors, trials
CDKN2A
Deleted (poor prog.)
Antioxidants, IF fasting
Palbociclib, ribociclib
TP53
Mutated (aggressive)
Low-sugar diet, IF fasting
APR-246, PRIMA-1MET
BIOMARKERS
CD99
High expression
Regular follow-up, imaging
Anti-CD99 immunotherapy
LDH
>200 U/L (poor prog.)
Exercise, hydration
CoQ10, NAC, vitamin D
NSE
Elevated (active disease)
Stress mgmt., sleep hygiene
B vitamins, magnesium
NKX2.2
Overexpressed
Anti-inflam. diet, exercise
Tazemetostat (EZH2-i)