Femur Fracture Risk — Genes & Biomarkers Summary
Biomarker / Gene
Bad Score
Free Actions
Non-free Actions
GENES
COL1A1
Ss / ss allele
Exercise, calcium-rich diet
Genetic counseling, bisphosphonates
VDR
ff genotype
Sun exposure, vit D foods
Vitamin D supplements
LRP5
Low-function variant
Weight-bearing exercise
DXA scan, bisphosphonates
RANKL (TNFSF11)
Overexpression allele
Anti-inflammatory diet
Denosumab
BIOMARKERS
Vitamin D (25-OH)
< 20 ng/mL
Sunlight, dairy products
Vitamin D / calcium supplements
CTX (C-telopeptide)
> 0.57 ng/mL
Reduce alcohol & smoking
Bisphosphonates
P1NP
< 25 µg/L
Protein diet, exercise
Teriparatide (anabolic therapy)
FRAX Score
> 20% (10-yr risk)
Fall prevention, balance training
Osteoporosis medication