GCTB — Genes & Biomarkers Summary
Biomarker / Gene
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H3F3A(gene)
G34W mutation
IHC staining,lit. review
NGS testing,targeted therapy
RANKL(gene)
Overexpression
Bone densitymonitoring
Denosumab (Xgeva)
TP53(gene)
Loss of function
Regular imagingfollow-up
Chemotherapy
Ki-67(biomarker)
>10% index
Clinicalsurveillance
Surgery / radiotherapy
VEGF(biomarker)
High level
Anti-inflam.lifestyle
Bevacizumab + resection
OPG(biomarker)
Low expression
Calcium + Vit D
Bisphosphonates
MMP-9(biomarker)
Elevated
Physical rehab
MMP inhibitors