Gonococcal Arthritis — Genes & Biomarkers Biomarker / Gene Bad Score Free Actions Non-free Actions HLA-B27 B*27 allele present Physiotherapy, monitoring Immunomodulators, biologics penA Mosaic allele detected Contact tracing, safe sex Cephalosporin therapy mtrR Resistance mutation Partner notification Dual antibiotic regimen CRP >10 mg/L Rest, hydration NSAIDs, IV antibiotics ESR >20 mm/hr Rest, physiotherapy Anti-inflammatory drugs Synovial WBC >50,000/µL Joint rest, elevation Aspiration, IV antibiotics IL-6 >7 pg/mL Anti-inflammatory diet IL-6 inhibitors, steroids Blue rows: Genes (HLA-B27, penA, mtrR) · Gray rows: Biomarkers (CRP, ESR, Synovial WBC, IL-6)