Hemarthrosis: Genes & Biomarkers Summary
Gene / Biomarker
Bad Score
Free Actions
Non-free Actions
GENES
BIOMARKERS
F8
F9
VWF
F13A1
PROS1
FVIII/FIX Activity
aPTT
VWF Panel
hs-CRP / IL-6
Ferritin/Iron Panel
MMP-3
FVIII <1% → severe HA
Family hx, joint diary
Genetic test, FVIII Rx
FIX <1% → severe HB
Joint protect, physio
FIX replacement, gene Rx
VWF:Ag <30 IU/dL
No NSAIDs, bleed diary
VWF/FVIII concentrate
Clot instability risk
Avoid trauma
FXIII concentrate, FFP
Protein S deficiency
Activity monitoring
Anticoagulation therapy
<1% activity
Activity log, joint assess
Prophylaxis / on-demand
Prolonged >35 s
Re-test, symptom review
Factor assays, coag panel
VWF:Ag <30 IU/dL
Dietary iron, hydration
VWF concentrate, DDAVP
hs-CRP >10 mg/L
Ice, rest, elevate
NSAIDs, synovectomy
Ferritin >200 µg/L
Monitor joint drainage
Iron chelation, synovect.
>100 ng/mL
Joint monitor, physio
Synovectomy, biologics