IBD-Associated ArthropathyGenes & Biomarkers — Bad Scores and Action PlansBiomarker / GeneBad ScoreFree ActionsNon-free ActionsGENESHLA-B27Positive allelePhysiotherapy, posture trainingAnti-TNF biologicsTNF -308G>AAllele A: high TNFAnti-inflammatory dietAnti-TNF agentsIL-23R R381QRisk alleleExercise, gut health dietIL-23 inhibitorsBIOMARKERSCRP>10 mg/LRest, hydrationNSAIDs, corticosteroidsESR>30 mm/hLow-impact exerciseDMARDs (methotrexate)Calprotectin>200 µg/gFiber-rich dietVedolizumabASCAPositiveProbiotics, anti-inflam. dietImmunosuppressantspANCAPositiveOmega-3 diet5-ASA, azathioprineGenes (bold blue) · Biomarkers (dark gray) · IBD = Inflammatory Bowel Disease