JIA Biomarkers & Genes — Summary Table
Biomarker / Gene
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BIOMARKERS (7)
ESR (Erythrocyte Sed. Rate)
Elevated >20 mm/hr
Sleep 8-10h; gentle movement;
anti-inflammatory diet
Omega-3 EPA+DHA 1-2g/d;
curcumin+piperine 200-500mg/d
CRP (C-Reactive Protein)
>10 mg/L (std); >3 mg/L (hs)
Remove processed foods; 10-12h
eating window; stress reduction
Omega-3s; quercetin 125-250mg/d;
red light therapy (adjunctive)
ANA (Antinuclear Antibodies)
Titer >=1:80 speckled;
silent uveitis risk
Ophthalmology q3-6mo; gut
barrier health; limit UV exposure
Vit D3+K2; lutein+zeaxanthin
10-12mg/d; omega-3s (uveitis)
Ferritin
>500 ng/mL in sJIA (MAS);
rapidly rising = urgent
Track trends; manage infections;
no iron suppl.; reduce stress
Physician-guided only —
MAS is a medical emergency
Vitamin D (25-OH)
<20 ng/mL deficient;
<30 ng/mL insufficient
15-25 min midday sunlight;
fatty fish; egg yolks; liver
Vit D3+K2 1000-4000 IU/d;
magnesium glycinate 50-100mg/d
RF + Anti-CCP
Both positive (RF+ JIA);
worst joint prognosis
Dental hygiene; physiotherapy;
dietary elimination; no tobacco
Omega-3s 2-4g/d; selenium
(Brazil nuts); MTX + biologics
CBC with Differential
Hgb <10.5; PLT >400K;
falling WBC+PLT in sJIA = MAS
Iron-rich foods + vit C; hydration;
treat underlying inflammation
Iron bisglycinate 12-25mg/d;
folate 1mg/d + B12 (with MTX)
GENES (5)
HLA-B27
Present — ERA; axial risk;
anterior uveitis risk
Core exercises; ergonomic setup;
ophthalmology q1y; no tobacco
Omega-3s 2g/d; vit D3+K2;
spore-based probiotics; NSAIDs (MD)
HLA-DRB1 (Shared Epitope)
SE alleles — erosive JIA;
drives anti-CCP production
Dental hygiene (P. gingivalis);
eliminate secondhand smoke
Omega-3s 3-4g/d; selenium;
early MTX at diagnosis (MD)
PTPN22 (R620W)
Risk allele — impaired
T/B cell brake; raised autoimm. risk
Gut barrier support; consistent
sleep; manage infections; min. ABX
Probiotics (LGG + B. longum);
L-glutamine 2-5g/d; zinc picolinate
IL-6 (-174 G/C)
GG — high IL-6 expression;
severe sJIA course
Moderate exercise; cold showers;
body weight management
Magnesium glycinate; boswellia
100-200mg/d; tocilizumab (MD)
TNF-alpha (-308 G/A)
A allele — high TNF production;
aggressive early JIA
Regular exercise; sleep optim.;
polyphenols (berries, green tea)
Curcumin+piperine 200-500mg/d;
resveratrol 25-50mg/d; anti-TNF