Knee Sprain — Genes & Biomarkers Summary Gene / Biomarker Bad Score Free Actions Non-free Actions GENES BIOMARKERS COL1A1 COL5A1 MMP3 IL6 CRP IL-6 COMP MMP-3 TT genotype CC genotype 5A/5A genotype GG genotype >3 mg/L >5 pg/mL Elevated >10 ng/mL Strength training, collagen diet Eccentric stretching, PT Anti-inflammatory diet, rest Omega-3, cold therapy Regular exercise, sleep, diet Cold packs, omega-3, rest Load management, PT Physical therapy, activity rest Genetic / sports DNA panel COL5A1 sports genetics test Pharmacogenomics panel Sports medicine genetic consult NSAIDs, anti-inflam. drugs Anti-IL-6 biologic therapy MRI, orthopedic consult MMP inhibitor therapy