LCPD — Genes & Biomarkers Summary Gene / Biomarker Bad Score Free Actions Non-free Actions GENES COL2A1 Risk variant Avoid high-impact sport Genetic counseling ANKH Risk allele Low-impact exercise Orthopedic consult COMP Pathogenic variant Joint load restriction Physical therapy COL9A1 Risk variant Monitor joint health MRI surveillance BIOMARKERS CRP > 10 mg/L Rest, anti-inflam. diet NSAIDs / steroids ESR > 20 mm/h Activity reduction Lab investigation IL-6 > 7 pg/mL Anti-inflammatory diet Biologic therapy IGF-1 < 100 ng/mL Nutritional optimization Endocrinology referral