Osteoarthritis — Genes & Biomarkers Summary
Biomarker / Gene
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GENES
BIOMARKERS
GDF5
COL2A1
IL1B
TGFB1
hs-CRP
COMP
CTX-II
IL-6
T/T risk allele
Risk variants present
Pro-inflam. allele
Risk variants
>3 mg/L
Elevated (>12 U/L)
High urinary levels
>5 pg/mL
Exercise, healthy weight
Low-impact exercise
Anti-inflam. diet, cold therapy
Yoga, stretching, rest
Anti-inflam. diet, aerobics
Low-impact activity, weight ctrl
Weight loss, reduce joint load
Stress reduction, exercise
Glucosamine, fish oil
Collagen peptides, knee brace
NSAIDs, IL-1 inhibitors
PRP injections, supplements
Omega-3, curcumin
Knee brace, monitoring kit
Hyaluronic acid injections
Anti-IL-6 therapy