OCD — Biomarkers & Genes: Risk Summary
Biomarker / Gene
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BIOMARKERS (7)
Vitamin D (25-OH-D)
<20 ng/mL deficiency
Midday sun 15-30 min; fatty fish
D3 2,000-5,000 IU/day + K2 MK-7
IGF-1
Low for age bracket
Resistance training; protein; 7-9h sleep
Zinc 15-30mg; Mg glycinate; ashwagandha
hsCRP
>1 mg/L elevated
Clean diet; Zone 2 cardio 3-5x/wk
Omega-3 2-4g/day; curcumin + piperine
CTX-1
>0.4 ng/mL (men)
Weight-bearing exercise; adequate protein
Calcium + D3/K2; collagen peptides 10g
P1NP
Low / not trending up
Mechanical loading; vitamin D; sleep
Vitamin K2 MK-7 180-360mcg; boron 3-6mg
COMP
>10 U/L (rising)
Activity mod.; pain-free ROM exercises
UC-II collagen 40mg; oral HA 80-200mg
Ferritin / Iron
Ferritin <50 ng/mL
Red meat; vitamin C alongside plant iron
Ferrous bisglycinate 25-50mg alt. days
GENES (4)
COL2A1 (gene)
Risk variant
Low-impact training; gait retraining
UC-II collagen 40mg; vitamin C; orthotics
ACAN (gene)
Risk variant
Hydration 2-3L/day; gentle ROM daily
Glucosamine 1,500mg/day; chondroitin
GDF5 (gene)
Risk variant
Biomechanics training; gait therapy
LLLT 830nm; omega-3 2-3g/day; orthotics
MMP13 (gene)
High expression risk
Periodize training; deload weeks; sleep
Curcumin + piperine; resveratrol; EGCG