Osteochondroma - Genes & Biomarkers: Scores & Action Plans
Gene / BiomarkerBad ScoreFree ActionsNon-free Actions
EXT1
Gene: tumor suppressor
High - LoF mut.
Monitor growthavoid impact sports
Genetic counselingsurgical excision
EXT2
Gene: exostosin
High - LoF mut.
Family awarenessregular check-ups
Genetic testingorthopedic follow-up
Heparan Sulfate
Biomarker: HSPG ↓
High - ↓ synthesis
Anti-inflam. dietomega-3 intake
HSPG assaybiochemical workup
Alkaline Phosphatase
Biomarker: ALP ↑
Med - elevated
Vitamin D & calciumbalanced nutrition
Bone density scanlab ALP test
IGF-1
Biomarker: growth factor ↑
Med - elevated
Low-GI dietsleep hygiene
Endocrinology consultIGF-1 serum test
FGF Signaling
Biomarker: pathway dysreg.
Med - dysreg.
Anti-inflam. lifestylelimit growth triggers
FGF inhibitor trialtargeted therapy ref.
LoF = Loss of Function · HSPG = Heparan Sulfate Proteoglycan · IGF-1 = Insulin-like Growth Factor 1 · FGF = Fibroblast Growth Factor