Osteomalacia — Genes & Biomarkers Summary
Biomarker / GeneBad ScoreFree ActionsNon-free Actions
VDRRisk alleleSun exposure, vit D foodsVit D3 supp., VDR agonists
CYP27B1Pathogenic variantSun exposure, dairy dietCalcitriol (1,25-D)
PHEXLoss-of-func. var.Phosphate-rich dietPhosphate + calcitriol
FGF23 (gene)Gain-of-func. var.Treat iron deficiencyBurosumab (anti-FGF23)
25-OH Vit D<20 ng/mLSun 15–30 min/dayVit D3 supp. / UV lamp
Phosphate<0.8 mmol/LPhosphate-rich foodsPhosphate supplement
PTH>65 pg/mLCalcium intake, sunCalcitriol
ALP>120 U/LWeight-bearing exerciseBisphosphonates
Thresholds are indicative; consult a physician for diagnosis.