Osteoporosis — Genes & Biomarkers Summary
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GENES
VDRFokI/BsmI risk allelesSun exposure; weight trainingVit D3 suppl.; genetic test
COL1A1Sp1 G/T polymorphismCa-rich diet; quit smokingDEXA scan; bisphosphonates
LRP5Loss-of-function (A1330V)Weight-bearing exercise; CaBone density test; anabolics
ESR1XbaI/PvuII risk allelesPhytoestrogen diet; exerciseHRT; SERM therapy
SOSTHigh-expression variantsImpact exercise; Ca+D dietRomosozumab; DEXA scan
BIOMARKERS
CTX>0.57 ng/mL (high resorption)No alcohol/smoking; exerciseBisphosphonates; denosumab
P1NP>59 μg/L (high formation)Resistance training; Ca dietTeriparatide; romosozumab
Vitamin D<20 ng/mL (deficiency)Sun 15-30 min/day; oily fishVit D3/D2 supplements
PTH>65 pg/mL (elevated)Ca-rich diet; sun exposureCinacalcet; Ca supplements
Osteocalcin<11 ng/mL (low formation)Exercise; Vit K-rich foodsVit K2 suppl.; anabolics
Sclerostin>32 pmol/L (high inhibition)Impact/resistance exerciseRomosozumab; monitoring
Magnesium<0.75 mmol/L (deficiency)Nuts; leafy greens; sleepMg supplements; IV Mg