Osteosarcoma — Genes & Biomarkers Summary
Gene / BiomarkerBad ScoreFree ActionsNon-free Actions
TP53GenePathogenic mutationGenetic counseling;family screeningTumor NGS panel
RB1GeneBiallelic lossOphthalmic surveillanceArray CGH / WGS
RECQL4GeneGermline variantFamily history reviewHereditary gene panel
DLG2GeneHemizygous deletionLifestyle surveillanceSNP / CNV array
RUNX2GeneOverexpressionClinical risk assessmentIHC tissue profiling
ALPBiomarkerElevated (>2× ULN)Standard blood panelBone-specific ALP assay
LDHBiomarkerElevated (>ULN)Routine lab workupLDH isoenzyme assay
VEGFBiomarkerHigh expressionClinical observationSerum VEGF assay