PAD Genes & Biomarkers — Summary Table Biomarker / GeneBad ScoreFree ActionsNon-free Actions GENES PCSK9Risk variantLow sat-fat diet, exercisePCSK9 inhibitors 9p21Risk alleleHeart-healthy diet, exerciseStatin therapy MTHFRTT genotypeFolate & B-vitamin dietMethylfolate suppl. Factor V LeidenMutation presentAvoid immobility, hydrateAnticoagulants (DOAC) eNOS (NOS3)Risk variantExercise, L-arginine foodsNO-boosting suppl. APOEε4 alleleLow-fat diet, omega-3Statins, fibrates BIOMARKERS ABI< 0.9Walking, quit smokingSupervised exercise, surgery Lp(a)> 50 mg/dLLow refined-carb dietNiacin, PCSK9 inhibitors ApoB> 100 mg/dLDiet, exerciseStatins, PCSK9 inhibitors hsCRP> 3 mg/LAnti-inflammatory dietStatins (pleiotropic) Homocysteine> 15 µmol/LB-vitamin rich dietFolate/B12 supplements Fibrinogen> 400 mg/dLExercise, omega-3 dietFibrates, statins D-dimer> 500 ng/mLHydration, mobilityAnticoagulation therapy