Patellar Dislocation — Biomarkers & Genes
Biomarker / Gene
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BIOMARKERS
COL5A1
Gene
TT genotype
Eccentric loading · backward walking
Collagen 10–15g + vit C · patellar brace
TNXB
Gene
LOF variant
VMO + glute med strengthening · perturbation
Rigid patellar brace · vit C + glycine 5g
GDF5
Gene
rs143384 risk allele
VMO exercises · hip abductor strengthening
Glucosamine 1500mg + chondroitin 1200mg
FBN1
Gene
Subclinical variant
Controlled resistance training · no end-range
Mg taurate 400mg · omega-3 2–3g · knee brace
MMP3
Gene
High-activity variant
Mediterranean diet · sleep · early mobilization
EGCG 400–600mg · curcumin + piperine
ACTN3
Gene
XX genotype (R577X)
Perturbation training · hop-landing drills
Creatine 3–5g/day · caffeine 3–6mg/kg
Vitamin D
Biomarker
< 30 ng/mL
Midday sun 15–30 min · fatty fish 3–4×/week
D3 4000–5000 IU + K2 MK-7 100–200mcg
Estradiol
Biomarker
Peak ovulatory ↑
Cycle tracking · cruciferous veg · no alcohol
DIM 100–200mg · flaxseed 2 tbsp/day
hsCRP
Biomarker
> 3.0 mg/L
Mediterranean diet · 7–9h sleep · stress mgmt
Omega-3 EPA+DHA 2–4g · curcumin + piperine
Testosterone
Biomarker
M <600; F <15 ng/dL
Resistance training 3–4×/wk · dietary fat 25–35%
KSM-66 ashwagandha 300–600mg · vit D3
Magnesium
Biomarker (RBC)
RBC < 4.2 mg/dL
Pumpkin seeds · dark greens · reduce alcohol
Magnesium glycinate 300–400mg evening
IGF-1
Biomarker
< 150 ng/mL
Heavy resistance training · protein 1.6–2.2g/kg
Creatine 3–5g · glycine 5g before sleep
CTX / P1NP
Biomarker
High CTX + low P1NP
Weight-bearing exercise · calcium-rich foods
Collagen peptides 10–15g + vit C · K2 MK-7