Psoriatic Arthritis — 6 Biomarkers & 5 Genes: Reference Table Biomarker / Gene Red Flag Free Action Plan Supplement / Equipment Plan BIOMARKERS hsCRP (Biomarker) >3 mg/L Mediterranean diet, 7–9h sleep, 150 min aerobic exercise/week Omega-3 EPA/DHA 2–4g/day, Curcumin BCM-95 500–1000mg/day, Boswellia AKBA 300–500mg ESR (Biomarker) >20 mm/hr (F) >15 mm/hr (M) Anti-inflam. diet, fermented foods, check ferritin to rule out anemia Probiotics 10–50B CFU/day, L-glutamine 5–10g/day, Infrared sauna 15–20min 3–4x/wk 25-OH Vitamin D (Biomarker) <30 ng/mL (<20 ng/mL = deficient) 20–30 min sun/day (10am–2pm), oily fish, narrowband UVB at home Vitamin D3 2000–5000 IU/day + K2 MK-7 100–200mcg/day; retest after 3 months Uric Acid (Biomarker) >5.5 mg/dL Eliminate fructose beverages & purines, hydrate 2–3L/day, moderate aerobic exercise Tart cherry extract 480mg anthocyanins/day, Quercetin 500mg/day, Vitamin C 500mg/day IL-17A (Biomarker) >10 pg/mL 30g+ fiber/day from diverse plants, fermented foods daily, cold showers Omega-3 EPA/DHA 3–4g/day, Vitamin D3 (target >50 ng/mL), Berberine 500mg 2x/day HOMA-IR (Biomarker) >2.0 (meaningful) >2.5 (significant) Strength training 2–3x/wk, 14–16h fasting window, post-meal 10–20 min walks Berberine 500mg 2–3x/day, Magnesium glycinate 300–400mg, ALA 300–600mg/day GENES HLA-B27 (Gene) Positive result Daily spinal mobility exercises, swimming, firm mattress, quit smoking D3 + K2 (target >55 ng/mL), Omega-3 3–4g, NAC 600mg 2x/day, Lactobacillus 10–20B CFU HLA-C*06:02 / Cw6 (Gene) Allele present Protect skin from trauma, treat strep promptly, narrowband UVB 2x/week D3 3000–5000 IU + calcipotriol cream, Silymarin 300mg 2x/day, NAC 600mg 2x/day IL23R (Gene) Risk variant present 35–40g fiber/day, 30+ plant species/wk, fermented foods daily, cold showers Curcumin BCM-95 1000mg, Berberine 500mg 2x, Resveratrol 500mg + Quercetin 500mg with meal TNFA (Gene) High-risk allele 7–9h sleep, 14h+ overnight fast, Mediterranean diet PEA 600mg 2x/day, EGCG 400mg, Omega-3 3–4g/day, Boswellia AKBA 300–500mg PTPN22 (Gene) R620W variant 7–9h sleep, moderate exercise only, reduce gut permeability triggers Methylcobalamin B12 1000mcg + methylfolate 400–800mcg, Zinc picolinate 15–25mg/day Source: GWAS and clinical biomarker studies in psoriatic arthritis