PVNS — Genes & Biomarkers Summary
Biomarker / Gene
Bad Score
Free Actions
Non-free Actions
CSF1 (G)
Translocation / overexp.
Monitor symptoms
Pexidartinib
COL6A3 (G)
CSF1 fusion detected
Low-impact exercise
Synovectomy
HMGA2 (G)
Overexpression
Anti-inflammatory diet
Targeted therapy
CSF1R (B)
High receptor density
Joint protection
CSF1R inhibitor
M-CSF (B)
Elevated serum level
Omega-3 rich diet
Anti-CSF1R therapy
CD68 (B)
High macrophage count
Ice / heat therapy
Steroid injection
TNF-α (B)
Elevated in synovium
Rest, cold compress
Anti-TNF biologics
MMP-3 (B)
High synovial level
Gentle mobility
NSAIDs / surgery
(G) = Gene (B) = Biomarker