Rheumatic Fever — Genes & Biomarkers
Bad score thresholds and action plans
Biomarker / Gene
Bad Score
Free Actions
Non-free Actions
GENES
HLA-DRB1*07
Carrier allele
Hygiene, avoid crowding
HLA typing, counseling
TNFA -308A
Variant present
Anti-inflammatory diet
Pharmacogenomic panel
MBL2
Low expression
Infection prevention
Immunologist referral
TLR2 (Arg753Gln)
Risk variant
Hygiene, prompt treatment
Immunologic workup
BIOMARKERS
ASO titer
>200 IU/mL
Rest, hydration
Penicillin prophylaxis
Anti-DNase B
>240 IU/mL
Monitor symptoms
Serology panel
CRP
>10 mg/L
Anti-inflammatory diet
NSAIDs, cardiology consult
ESR
>30 mm/h
Rest, hydration
Full inflammatory panel