Sickle Cell Disease — Genes & Biomarkers
Biomarker / Gene
Bad Score
Free Actions
Non-free Interventions
GENES
HBB (β-globin)
HbSS genotype
Hydration, avoid cold/stress
Hydroxyurea, gene therapy
BCL11A
Low expression
—
CRISPR gene editing
HBG1 / HBG2
Low γ-globin activity
—
HbF-inducing agents
BIOMARKERS
HbS (%)
>85%
Hydration, avoid triggers
Exchange transfusion
HbF (%)
<5%
—
Hydroxyurea, voxelotor
WBC count
>15 G/L
Avoid infections
Antibiotics, vaccines
LDH
Elevated
Rest, hydration
L-glutamine, crizanlizumab
Bilirubin
Elevated
Hydration
Cholecystectomy (if stones)