Sciatica Genes & Biomarkers Biomarker / Gene Bad Score Free Actions Non-free Actions GENES MMP3 High expression Anti-inflam. diet Microdiscectomy IL-6 (gene) rs1800795 variant Cold/heat therapy Biologic therapy COL9A2 Trp2 allele Weight management Epidural injection BIOMARKERS IL-6 >7 pg/mL Ice packs, yoga NSAIDs, biologics TNF-α Elevated serum Rest, walking Anti-TNF therapy CRP >10 mg/L Healthy diet, sleep Corticosteroids